Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

PURPOSE: Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a distinct biology and natural history. The therapeutic value of cytoreductive surgery and radiation therapy for posterior fossa ependymoma after accounting for molecular subgroup is no...

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Pubblicato in:J Clin Oncol
Autori principali: Ramaswamy, Vijay, Hielscher, Thomas, Mack, Stephen C., Lassaletta, Alvaro, Lin, Tong, Pajtler, Kristian W., Jones, David T.W., Luu, Betty, Cavalli, Florence M.G., Aldape, Kenneth, Remke, Marc, Mynarek, Martin, Rutkowski, Stefan, Gururangan, Sridharan, McLendon, Roger E., Lipp, Eric S., Dunham, Christopher, Hukin, Juliette, Eisenstat, David D., Fulton, Dorcas, van Landeghem, Frank K.H., Santi, Mariarita, van Veelen, Marie-Lise C., Van Meir, Erwin G., Osuka, Satoru, Fan, Xing, Muraszko, Karin M., Tirapelli, Daniela P.C., Oba-Shinjo, Sueli M., Marie, Suely K.N., Carlotti, Carlos G., Lee, Ji Yeoun, Rao, Amulya A. Nageswara, Giannini, Caterina, Faria, Claudia C., Nunes, Sofia, Mora, Jaume, Hamilton, Ronald L., Hauser, Peter, Jabado, Nada, Petrecca, Kevin, Jung, Shin, Massimi, Luca, Zollo, Massimo, Cinalli, Giuseppe, Bognár, László, Klekner, Almos, Hortobágyi, Tibor, Leary, Sarah, Ermoian, Ralph P., Olson, James M., Leonard, Jeffrey R., Gardner, Corrine, Grajkowska, Wieslawa A., Chambless, Lola B., Cain, Jason, Eberhart, Charles G., Ahsan, Sama, Massimino, Maura, Giangaspero, Felice, Buttarelli, Francesca R., Packer, Roger J., Emery, Lyndsey, Yong, William H., Soto, Horacio, Liau, Linda M., Everson, Richard, Grossbach, Andrew, Shalaby, Tarek, Grotzer, Michael, Karajannis, Matthias A., Zagzag, David, Wheeler, Helen, von Hoff, Katja, Alonso, Marta M., Tuñon, Teresa, Schüller, Ulrich, Zitterbart, Karel, Sterba, Jaroslav, Chan, Jennifer A., Guzman, Miguel, Elbabaa, Samer K., Colman, Howard, Dhall, Girish, Fisher, Paul G., Fouladi, Maryam, Gajjar, Amar, Goldman, Stewart, Hwang, Eugene, Kool, Marcel, Ladha, Harshad, Vera-Bolanos, Elizabeth, Wani, Khalida, Lieberman, Frank, Mikkelsen, Tom, Omuro, Antonio M., Pollack, Ian F., Prados, Michael, Robins, H. Ian, Soffietti, Riccardo, Wu, Jing, Metellus, Phillipe, Tabori, Uri, Bartels, Ute, Bouffet, Eric, Hawkins, Cynthia E., Rutka, James T., Dirks, Peter, Pfister, Stefan M., Merchant, Thomas E., Gilbert, Mark R., Armstrong, Terri S., Korshunov, Andrey, Ellison, David W., Taylor, Michael D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2016
Soggetti:
Original Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962737/
https://ncbi.nlm.nih.gov/pubmed/27269943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.65.7825
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