Indirubin-3′-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperphosphorylation

Indirubin-3′-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. Here, we found that indirubin-3′-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-...

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Detalhes bibliográficos
Publicado no:Neural Regen Res
Main Authors: Zhang, Shu-gang, Wang, Xiao-shan, Zhang, Ying-dong, Di, Qing, Shi, Jing-ping, Qian, Min, Xu, Li-gang, Lin, Xing-jian, Lu, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications & Media Pvt Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962599/
https://ncbi.nlm.nih.gov/pubmed/27482230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1673-5374.184500
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