Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity

Neuronal insulin resistance is a significant feature of Alzheimer’s disease (AD). Accumulated evidence has revealed the possible neuroprotective mechanisms of antidiabetic drugs in AD. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog and an antidiabetic agent, has a benefit in improving a perip...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Jantrapirom, Salinee, Nimlamool, Wutigri, Chattipakorn, Nipon, Chattipakorn, Siriporn, Temviriyanukul, Piya, Inthachat, Woorawee, Govitrapong, Piyarat, Potikanond, Saranyapin
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084306/
https://ncbi.nlm.nih.gov/pubmed/32138327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21051725
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