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An activating KIT mutation induces crizotinib resistance in ROS1 positive lung cancer

INTRODUCTION: Non-small cell lung cancer (NSCLC) patients with ROS1 chromosomal rearrangements benefit from treatment with the ROS1 inhibitor crizotinib. Limited data exist on the spectrum of resistance mechanisms in ROS1+ NSCLC. To delineate mechanisms of acquired resistance, we analyzed tumor samp...

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書誌詳細
出版年:J Thorac Oncol
主要な著者: Dziadziuszko, Rafal, Le BA, Anh T., Wrona, Anna, Jassem, Jacek, Camidge, D. Ross, Varella-Garcia, Marileila, Aisner, Dara L., Doebele, Robert C.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961521/
https://ncbi.nlm.nih.gov/pubmed/27068398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2016.04.001
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