Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent

Mycobacterium abscessus (Mabs) is a rapidly growing Mycobacterium and an emerging pathogen in humans. Transitioning from a smooth (S) high-glycopeptidolipid (GPL) producer to a rough (R) low-GPL producer is associated with increased virulence in zebrafish, which involves the formation of massive ser...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Halloum, Iman, Carrère-Kremer, Séverine, Blaise, Mickael, Viljoen, Albertus, Bernut, Audrey, Le Moigne, Vincent, Vilchèze, Catherine, Guérardel, Yann, Lutfalla, Georges, Herrmann, Jean-Louis, Jacobs, William R., Kremer, Laurent
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961194/
https://ncbi.nlm.nih.gov/pubmed/27385830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605477113
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