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Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history
The hydrolytic deamination of cytosine and 5-methylcytosine residues in DNA appears to contribute significantly to the appearance of spontaneous mutations in microorganisms and in human disease. In the present work, we examined the mechanism of cytosine deamination and the response of the uncatalyze...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4961170/ https://ncbi.nlm.nih.gov/pubmed/27382162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607580113 |
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