A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models

A disintegrin and metalloproteinase 8 (ADAM8) has been identified as a signature gene associated with moderate and severe asthma. Studies in mice have demonstrated that the severity of asthma can be reduced by either transgenic knock-out or by antibodies blocking ADAM8 function, highlighting ADAM8 a...

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Udgivet i:Sci Rep
Main Authors: Chen, Jun, Deng, Linhong, Dreymüller, Daniela, Jiang, Xuemei, Long, Jiaoyue, Duan, Yiyuan, Wang, Yue, Luo, Mingzhi, Lin, Feng, Mao, Lizhen, Müller, Bernd, Koller, Garrit, Bartsch, Jörg W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960557/
https://ncbi.nlm.nih.gov/pubmed/27458083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30451
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