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Role of α4-containing GABA(A) receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period

Expression of α4βδ GABA(A) receptors (GABARs) increases at the onset of puberty on dendritic spines of CA1 hippocampal pyramidal cells. These receptors reduce activation of NMDA receptors (NMDARs), impair induction of long-term potentiation (LTP) and reduce hippocampal-dependent spatial learning. Th...

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Bibliografiske detaljer
Udgivet i:Brain Res
Main Authors: Shen, Hui, Sabaliauskas, Nicole, Yang, Lie, Aoki, Chiye, Smith, Sheryl S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959998/
https://ncbi.nlm.nih.gov/pubmed/26826007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2016.01.020
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