Involvement of the Eukaryote-Like Kinase-Phosphatase System and a Protein That Interacts with Penicillin-Binding Protein 5 in Emergence of Cephalosporin Resistance in Cephalosporin-Sensitive Class A Penicillin-Binding Protein Mutants in Enterococcus faecium

The intrinsic resistance of Enterococcus faecium to ceftriaxone and cefepime (here referred to as “cephalosporins”) is reliant on the presence of class A penicillin-binding proteins (Pbps) PbpF and PonA. Mutants lacking these Pbps exhibit cephalosporin susceptibility that is reversible by exposure t...

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Publicado no:mBio
Main Authors: Desbonnet, Charlene, Tait-Kamradt, Amelia, Garcia-Solache, Monica, Dunman, Paul, Coleman, Jeffrey, Arthur, Michel, Rice, Louis B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959515/
https://ncbi.nlm.nih.gov/pubmed/27048803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02188-15
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