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Dimers of melampomagnolide B exhibit potent anticancer activity against hematological and solid tumor cells

A series of novel carbamate and carbonate dimers of melampomagnolide B (MMB) have been synthesized by reaction of the MMB-triazole carbamate synthon 6 with various terminal diamino and dihydroxy alkanes. The resulting dimeric products 7b, 7c and 7f were selected and evaluated for anticancer activity...

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Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Janganati, Venumadhav, Ponder, Jessica, Jordan, Craig T., Borrelli, Michael J., Penthala, Narsimha Reddy, Crooks, Peter A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959447/
https://ncbi.nlm.nih.gov/pubmed/26540463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01187
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