Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents.

Phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cAMP-dependent protein kinase leads to chloride flux in epithelial cells. Is CFTR also required for the calcium-dependent activation of chloride channels? We used antisense oligodeoxynucleotides to CFTR to reduce th...

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Detalhes bibliográficos
Main Authors: Wagner, J A, McDonald, T V, Nghiem, P T, Lowe, A W, Schulman, H, Gruenert, D C, Stryer, L, Gardner, P
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC49588/
https://ncbi.nlm.nih.gov/pubmed/1379720
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