Combined cisplatin and aurora inhibitor treatment increase neuroblastoma cell death but surviving cells overproduce BDNF

Drug-resistance to chemotherapics in aggressive neuroblastoma (NB) is characterized by enhanced cell survival mediated by TrkB and its ligand, brain-derived neurotrophic factor (BDNF); thus reduction in BDNF levels represent a promising strategy to overcome drug-resistance, but how chemotherapics re...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Polacchini, Alessio, Albani, Clara, Baj, Gabriele, Colliva, Andrea, Carpinelli, Patrizia, Tongiorgi, Enrico
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958269/
https://ncbi.nlm.nih.gov/pubmed/27256407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.016725
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