Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity

Human African trypanosomiasis (HAT) is a major tropical disease for which few drugs for treatment are available, driving the need for novel active compounds. Recently, morpholino-substituted benzyl amides of the fluoroquinolone-type antibiotics were identified to be compounds highly active against T...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Hiltensperger, Georg, Hecht, Nina, Kaiser, Marcel, Rybak, Jens-Christoph, Hoerst, Alexander, Dannenbauer, Nicole, Müller-Buschbaum, Klaus, Bruhn, Heike, Esch, Harald, Lehmann, Leane, Meinel, Lorenz, Holzgrabe, Ulrike
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Chemistry; Biosynthesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958235/
https://ncbi.nlm.nih.gov/pubmed/27139467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01757-15
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