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Eravacycline Pharmacokinetics and Challenges in Defining Humanized Exposure In Vivo

We assessed the pharmacokinetic profile of eravacycline, a novel antibiotic of the tetracycline class, and determined the dose in an immunocompetent murine thigh infection model that would provide free-drug exposure similar to that observed in humans after the administration of 1 mg/kg intravenously...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Thabit, Abrar K., Monogue, Marguerite L., Nicolau, David P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958217/
https://ncbi.nlm.nih.gov/pubmed/27353264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00240-16
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