Pyrazinamide Is Active against Mycobacterium tuberculosis Cultures at Neutral pH and Low Temperature

For the past decades, an acidic pH has been used to render Mycobacterium tuberculosis susceptible to pyrazinamide for in vitro testing. Here, we show that at the standard breakpoint concentration and reduced culture temperatures, pyrazinamide (PZA) is active against tuberculosis (TB) at neutral pH....

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: den Hertog, Alice L., Menting, Sandra, Pfeltz, Richard, Warns, Matthew, Siddiqi, Salman H., Anthony, Richard M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Susceptibility
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958174/
https://ncbi.nlm.nih.gov/pubmed/27270287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00654-16
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