Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors

Missense mutations in ATM kinase, a master regulator of DNA damage responses, are found in many cancers, but their impact on ATM function and implications for cancer therapy are largely unknown. Here we report that 72% of cancer-associated ATM mutations are missense mutations that are enriched aroun...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Yamamoto, Kenta, Wang, Jiguang, Sprinzen, Lisa, Xu, Jun, Haddock, Christopher J, Li, Chen, Lee, Brian J, Loredan, Denis G, Jiang, Wenxia, Vindigni, Alessandro, Wang, Dong, Rabadan, Raul, Zha, Shan
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957979/
https://ncbi.nlm.nih.gov/pubmed/27304073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14709
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