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EGFR C797S mutation mediates resistance to third-generation inhibitors in T790M-positive non-small cell lung cancer
T790M mutation is the most common mechanism for resistance to first- and second-generation tyrosine kinase inhibitors (TKI) for epidermal growth factor receptor (EGFR). Several third-generation EGFR mutant selective TKIs are being explored to conquer this resistance. AZD9291 (osimertinib, tagrisso)...
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| Publicado no: | J Hematol Oncol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4957905/ https://ncbi.nlm.nih.gov/pubmed/27448564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0290-1 |
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