Requirement for a conserved serine in both processing and joining activities of retroviral integrase.

Retroviruses encode a protein, the integrase (IN), that is required for insertion of the viral DNA into the host cell chromosome. IN alone can carry out the integration reaction in vitro. The reaction involves endonucleolytic cleavage near the 3' ends of both viral DNA strands (the processing step),...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Katz, R A, Mack, J P, Merkel, G, Kulkosky, J, Ge, Z, Leis, J, Skalka, A M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1323118/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.15.6741
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