Retinal Neuroprotective Effects of Flibanserin, an FDA-Approved Dual Serotonin Receptor Agonist-Antagonist

PURPOSE: To assess the neuroprotective effects of flibanserin (formerly BIMT-17), a dual 5-HT(1A) agonist and 5-HT(2A) antagonist, in a light-induced retinopathy model. METHODS: Albino BALB/c mice were injected intraperitoneally with either vehicle or increasing doses of flibanserin ranging from 0.7...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Coyner, Aaron S., Ryals, Renee C., Ku, Cristy A., Fischer, Cody M., Patel, Rachel C., Datta, Shreya, Yang, Paul, Wen, Yuquan, Hen, René, Pennesi, Mark E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957778/
https://ncbi.nlm.nih.gov/pubmed/27447833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159776
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