Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity

BACKGROUND: In this phase 1 clinical trial, healthy adult, malaria-naïve subjects were immunized with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) by mosquito bite and then underwent controlled human malaria infection (CHMI). The PfRAS model for immunization against malaria had pre...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Hickey, Bradley W., Lumsden, Joanne M., Reyes, Sharina, Sedegah, Martha, Hollingdale, Michael R., Freilich, Daniel A., Luke, Thomas C., Charoenvit, Yupin, Goh, Lucy M., Berzins, Mara P., Bebris, Lolita, Sacci, John B., De La Vega, Patricia, Wang, Ruobing, Ganeshan, Harini, Abot, Esteban N., Carucci, Daniel J., Doolan, Denise L., Brice, Gary T., Kumar, Anita, Aguiar, Joao, Nutman, Thomas B., Leitman, Susan F., Hoffman, Stephen L., Epstein, Judith E., Richie, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957371/
https://ncbi.nlm.nih.gov/pubmed/27448805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-016-1435-y
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