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Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Among cis-Acting RNA Elements

West Nile virus (WNV) is a prototypical emerging virus for which no effective therapeutics currently exist. WNV uses programmed −1 ribosomal frameshifting (−1 PRF) to synthesize the NS1′ protein, a C terminally extended version of its non-structural protein 1, the expression of which enhances neuro-...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Moomau, Christine, Musalgaonkar, Sharmishtha, Khan, Yousuf A., Jones, John E., Dinman, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957060/
https://ncbi.nlm.nih.gov/pubmed/27226636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.735613
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