Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation

The biogenic amine serotonin (5-HT) is a multi-faceted hormone that is synthesized from dietary tryptophan with the rate limiting step being catalyzed by the enzyme tryptophan hydroxylase (TPH). The therapeutic potential of peripheral 5-HT synthesis inhibitors has been demonstrated in a number of cl...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Welford, Richard W. D., Vercauteren, Magali, Trébaul, Annette, Cattaneo, Christophe, Eckert, Doriane, Garzotti, Marco, Sieber, Patrick, Segrestaa, Jérôme, Studer, Rolf, Groenen, Peter M. A., Nayler, Oliver
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956766/
https://ncbi.nlm.nih.gov/pubmed/27444653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30059
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