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Mitochondrial pyruvate import promotes long-term survival of antibody-secreting plasma cells
Durable antibody production after vaccination or infection is mediated by long-lived plasma cells (LLPCs). Pathways that specifically allow LLPCs to persist remain unknown. Through bioenergetic profiling, we found that human and mouse LLPCs could robustly engage pyruvate-dependent respiration wherea...
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Publicado no: | Immunity |
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Main Authors: | , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4956536/ https://ncbi.nlm.nih.gov/pubmed/27396958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.06.011 |
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