Mitochondrial pyruvate import promotes long-term survival of antibody-secreting plasma cells

Durable antibody production after vaccination or infection is mediated by long-lived plasma cells (LLPCs). Pathways that specifically allow LLPCs to persist remain unknown. Through bioenergetic profiling, we found that human and mouse LLPCs could robustly engage pyruvate-dependent respiration wherea...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Lam, Wing Y., Becker, Amy M., Kennerly, Krista M., Wong, Rachel, Curtis, Jonathan D., Llufrio, Elizabeth M., McCommis, Kyle S., Fahrmann, Johannes, Pizzato, Hannah A., Nunley, Ryan M., Lee, Jieun, Wolfgang, Michael J., Patti, Gary J., Finck, Brian N., Pearce, Erika L., Bhattacharya, Deepta
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956536/
https://ncbi.nlm.nih.gov/pubmed/27396958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.06.011
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