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Importance of the evaluation of N-acetyltransferase enzyme activity prior to 5-aminosalicylic acid medication for ulcerative colitis

BACKGROUND: 5-aminosalicylic acid (5-ASA) is a classic anti-inflammatory drug for the treatment of ulcerative colitis. N-Acetyltransferase (NAT) enzymes convert 5-ASA to its metabolite N-acetyl-5-aminosalicylic acid (Ac-5-ASA) and it is unresolved whether 5-ASA or Ac-5-ASA is the effective therapeut...

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Detalhes bibliográficos
Publicado no:Inflamm Bowel Dis
Main Authors: Matthis, Andrea L., Zhang, Bin, Denson, Lee A., Yacyshyn, Bruce R., Aihara, Eitaro, Montrose, Marshall H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956520/
https://ncbi.nlm.nih.gov/pubmed/27416043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000823
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