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Development of a robust, sensitive and selective liquid chromatography-tandem mass spectrometry assay for the quantification of the novel macrocyclic peptide kappa opioid receptor antagonist [D-Trp]CJ-15,208 in plasma and application to an initial pharmacokinetic study

Selective kappa opioid receptor (KOR) antagonists may have therapeutic potential as treatments for substance abuse and mood disorders. Since [D-Trp]CJ-15,208 (cyclo[Phe-D-Pro-Phe-D-Trp]) is a novel potent KOR antagonist in vivo, it is imperative to evaluate its pharmacokinetic properties to assist t...

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書誌詳細
出版年:J Chromatogr B Analyt Technol Biomed Life Sci
主要な著者: Khaliq, Tanvir, Williams, Todd D., Senadheera, Sanjeewa N., Aldrich, Jane V.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956519/
https://ncbi.nlm.nih.gov/pubmed/27318293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.05.043
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