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Efficacy Coefficients Determined Using Nail Permeability and Antifungal Activity in Keratin-Containing Media Are Useful for Predicting Clinical Efficacies of Topical Drugs for Onychomycosis

Onychomycosis is difficult to treat topically due to the deep location of the infection under the densely keratinized nail plate. In order to obtain an in vitro index that is relevant to the clinical efficacy of topical anti-onychomycosis drugs, we profiled five topical drugs: amorolfine, ciclopirox...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Matsuda, Yoshiki, Sugiura, Keita, Hashimoto, Takashi, Ueda, Akane, Konno, Yoshihiro, Tatsumi, Yoshiyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956321/
https://ncbi.nlm.nih.gov/pubmed/27441843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159661
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