Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development

BACKGROUND: Accumulating evidence suggests that the C-C chemokine ligand 2 (CCL2, or monocyte chemoattractant protein 1) acts as a neuromodulator in the central nervous system through its binding to the C-C chemokine receptor 2 (CCR2). Notably, it is well established that the CCL2/CCR2 axis plays a...

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Опубликовано в: :Mol Pain
Главные авторы: Bégin-Lavallée, Valérie, Midavaine, Élora, Dansereau, Marc-André, Tétreault, Pascal, Longpré, Jean-Michel, Jacobi, Ashley M, Rose, Scott D, Behlke, Mark A, Beaudet, Nicolas, Sarret, Philippe
Формат: Artigo
Язык:Inglês
Опубликовано: SAGE Publications 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956154/
https://ncbi.nlm.nih.gov/pubmed/27306408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806916653969
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