In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on the design and validation of small interfering RNAs...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: ElHefnawi, Mahmoud, Kim, TaeKyu, Kamar, Mona A., Min, Saehong, Hassan, Nafisa M., El-Ahwany, Eman, Kim, Heeyoung, Zada, Suher, Amer, Marwa, Windisch, Marc P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956106/
https://ncbi.nlm.nih.gov/pubmed/27441640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159211
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