In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on the design and validation of small interfering RNAs...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: ElHefnawi, Mahmoud, Kim, TaeKyu, Kamar, Mona A., Min, Saehong, Hassan, Nafisa M., El-Ahwany, Eman, Kim, Heeyoung, Zada, Suher, Amer, Marwa, Windisch, Marc P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956106/
https://ncbi.nlm.nih.gov/pubmed/27441640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159211
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