Human memory T cells with a naïve phenotype accumulate with aging and respond to persistent viruses

The numbers of naive T cells decrease, and the susceptibility to new microbial infections increases with age. Here, we describe a new subset of phenotypically naive human CD8(+)T cells that rapidly secrete multiple cytokines in response to persistent viral antigens but differ transcriptionally from...

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Gepubliceerd in:Nat Immunol
Hoofdauteurs: Pulko, Vesna, Davies, John S., Martinez, Carmine, Lanteri, Marion C., Busch, Michael P., Diamond, Michael S., Knox, Kenneth, Busch, Erin S., Sims, Peter A., Sinari, Shripad, Billheimer, Dean, Haddad, Elias K., Murray, Kristy O., Wertheimer, Anne M., Nikolich-Žugich, Janko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955715/
https://ncbi.nlm.nih.gov/pubmed/27270402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3483
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