Human memory T cells with a naïve phenotype accumulate with aging and respond to persistent viruses

The numbers of naive T cells decrease, and the susceptibility to new microbial infections increases with age. Here, we describe a new subset of phenotypically naive human CD8(+)T cells that rapidly secrete multiple cytokines in response to persistent viral antigens but differ transcriptionally from...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Immunol
Hlavní autoři: Pulko, Vesna, Davies, John S., Martinez, Carmine, Lanteri, Marion C., Busch, Michael P., Diamond, Michael S., Knox, Kenneth, Busch, Erin S., Sims, Peter A., Sinari, Shripad, Billheimer, Dean, Haddad, Elias K., Murray, Kristy O., Wertheimer, Anne M., Nikolich-Žugich, Janko
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955715/
https://ncbi.nlm.nih.gov/pubmed/27270402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3483
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky