Human memory T cells with a naïve phenotype accumulate with aging and respond to persistent viruses

The numbers of naive T cells decrease, and the susceptibility to new microbial infections increases with age. Here, we describe a new subset of phenotypically naive human CD8(+)T cells that rapidly secrete multiple cytokines in response to persistent viral antigens but differ transcriptionally from...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Pulko, Vesna, Davies, John S., Martinez, Carmine, Lanteri, Marion C., Busch, Michael P., Diamond, Michael S., Knox, Kenneth, Busch, Erin S., Sims, Peter A., Sinari, Shripad, Billheimer, Dean, Haddad, Elias K., Murray, Kristy O., Wertheimer, Anne M., Nikolich-Žugich, Janko
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955715/
https://ncbi.nlm.nih.gov/pubmed/27270402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3483
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