Human memory T cells with a naïve phenotype accumulate with aging and respond to persistent viruses

The numbers of naive T cells decrease, and the susceptibility to new microbial infections increases with age. Here, we describe a new subset of phenotypically naive human CD8(+)T cells that rapidly secrete multiple cytokines in response to persistent viral antigens but differ transcriptionally from...

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Publié dans:Nat Immunol
Auteurs principaux: Pulko, Vesna, Davies, John S., Martinez, Carmine, Lanteri, Marion C., Busch, Michael P., Diamond, Michael S., Knox, Kenneth, Busch, Erin S., Sims, Peter A., Sinari, Shripad, Billheimer, Dean, Haddad, Elias K., Murray, Kristy O., Wertheimer, Anne M., Nikolich-Žugich, Janko
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955715/
https://ncbi.nlm.nih.gov/pubmed/27270402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3483
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