A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

BACKGROUND: Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)–propeller domains are the major determinant of resistance has p...

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Publicat a:N Engl J Med
Autors principals: Ménard, D., Khim, N., Beghain, J., Adegnika, A.A., Shafiul-Alam, M., Amodu, O., Rahim-Awab, G., Barnadas, C., Berry, A., Boum, Y., Bustos, M.D., Cao, J., Chen, J.-H., Collet, L., Cui, L., Thakur, G.-D., Dieye, A., Djallé, D., Dorkenoo, M.A., Eboumbou-Moukoko, C.E., Espino, F.-E.-C.J., Fandeur, T., Ferreira-da-Cruz, M.-F., Fola, A.A., Fuehrer, H.-P., Hassan, A.M., Herrera, S., Hongvanthong, B., Houzé, S., Ibrahim, M.L., Jahirul-Karim, M., Jiang, L., Kano, S., Ali-Khan, W., Khanthavong, M., Kremsner, P.G., Lacerda, M., Leang, R., Leelawong, M., Li, M., Lin, K., Mazarati, J.-B., Ménard, S., Morlais, I., Muhindo-Mavoko, H., Musset, L., Na-Bangchang, K., Nambozi, M., Niaré, K., Noedl, H., Ouédraogo, J.-B., Pillai, D.R., Pradines, B., Quang-Phuc, B., Ramharter, M., Randrianarivelojosia, M., Sattabongkot, J., Sheikh-Omar, A., Silué, K.D., Sirima, S.B., Sutherland, C., Syafruddin, D., Tahar, R., Tang, L.-H., Touré, O.A., Tshibangu-wa-Tshibangu, P., Vigan-Womas, I., Warsame, M., Wini, L., Zakeri, S., Kim, S., Eam, R., Berne, L., Khean, C., Chy, S., Ken, M., Loch, K., Canier, L., Duru, V., Legrand, E., Barale, J.-C., Stokes, B., Straimer, J., Witkowski, B., Fidock, D.A., Rogier, C., Ringwald, P., Ariey, F., Mercereau-Puijalon, O.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955562/
https://ncbi.nlm.nih.gov/pubmed/27332904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1513137
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