Paeoniflorin suppresses TGF-β mediated epithelial-mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway

AIM: Paeoniflorin has shown to attenuate bleomycin-induced pulmonary fibrosis (PF) in mice. Because the epithelial-mesenchymal transition (EMT) in type 2 lung endothelial cells contributes to excessive fibroblasts and myofibroblasts during multiple fibrosis of tissues, we investigated the effects of...

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Dettagli Bibliografici
Pubblicato in:Acta Pharmacol Sin
Autori principali: Ji, Yu, Dou, Yan-nong, Zhao, Qian-wen, Zhang, Ji-zhou, Yang, Yan, Wang, Ting, Xia, Yu-feng, Dai, Yue, Wei, Zhi-feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954768/
https://ncbi.nlm.nih.gov/pubmed/27133302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.36
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