Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes

AIM: To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on bone cancer pain (BCP) in rats. METHODS: A rat model of BCP was established by inoculating Walker 256 mammary carcinoma cells into tibial medullary canal. Two weeks later, the rats were injected with minocycl...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Song, Zhen-peng, Xiong, Bing-rui, Guan, Xue-hai, Cao, Fei, Manyande, Anne, Zhou, Ya-qun, Zheng, Hua, Tian, Yu-ke
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954763/
https://ncbi.nlm.nih.gov/pubmed/27157092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.1
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