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Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration

SGEF and Ephexin4 are members of the Ephexin subfamily of RhoGEFs that specifically activate the small GTPase RhoG. It is reported that Ephexin1 and Ephexin5, two well-characterized Ephexin subfamily RhoGEFs, are tyrosine-phosphorylated by Src, and that their phosphorylation affect their activities...

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Vydáno v:PLoS One
Hlavní autoři: Okuyama, Yusuke, Umeda, Kentaro, Negishi, Manabu, Katoh, Hironori
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954681/
https://ncbi.nlm.nih.gov/pubmed/27437949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159617
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