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Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration

SGEF and Ephexin4 are members of the Ephexin subfamily of RhoGEFs that specifically activate the small GTPase RhoG. It is reported that Ephexin1 and Ephexin5, two well-characterized Ephexin subfamily RhoGEFs, are tyrosine-phosphorylated by Src, and that their phosphorylation affect their activities...

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Publicat a:PLoS One
Autors principals: Okuyama, Yusuke, Umeda, Kentaro, Negishi, Manabu, Katoh, Hironori
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954681/
https://ncbi.nlm.nih.gov/pubmed/27437949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159617
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