Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen

Neprilysin (NEP) is an endogenous protease that degrades a wide range of peptides including amyloid beta (Aβ), the main pathological component of Alzheimer’s disease (AD). We have engineered NEP as a potential therapeutic for AD but found in pre-clinical safety testing that this variant increased pr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Burrell, Matthew, Henderson, Simon J., Ravnefjord, Anna, Schweikart, Fritz, Fowler, Susan B., Witt, Susanne, Hansson, Kenny M., Webster, Carl I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954676/
https://ncbi.nlm.nih.gov/pubmed/27437944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158114
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