Recurrent inactivating RASA2 mutations in melanoma

Analysis of 501 melanoma exomes revealed RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and...

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Udgivet i:Nat Genet
Main Authors: Arafeh, Rand, Qutob, Nouar, Emmanuel, Rafi, Keren-Paz, Alona, Madore, Jason, Elkahloun, Abdel, Wilmott, James S., Gartner, Jared J., Di Pizio, Antonella, Winograd-Katz, Sabina, Sindiri, Sivasish, Rotkopf, Ron, Dutton-Regester, Ken, Johansson, Peter, Pritchard, Antonia, Waddell, Nicola, Hill, Victoria K., Lin, Jimmy C., Hevroni, Yael, Rosenberg, Steven A., Khan, Javed, Ben-Dor, Shifra, Niv, Masha Y., Ulitsky, Igor, Mann, Graham J, Scolyer, Richard A., Hayward, Nicholas K., Samuels, Yardena
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954601/
https://ncbi.nlm.nih.gov/pubmed/26502337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3427
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