Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells

We have developed a robust, Good Manufacturing Practice-compatible differentiation protocol capable of producing scalable quantities of red blood cells (RBCs) from human pluripotent stem cells (hPSCs). However, translation of this protocol to the clinic has been compromised because the RBCs produced...

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Detalles Bibliográficos
Publicado en:Stem Cells Transl Med
Autores principales: Jackson, Melany, Ma, Rui, Taylor, A. Helen, Axton, Richard A., Easterbrook, Jennifer, Kydonaki, Maria, Olivier, Emmanuel, Marenah, Lamin, Stanley, Edouard G., Elefanty, Andrew G., Mountford, Joanne C., Forrester, Lesley M.
Formato: Artigo
Lenguaje:Inglês
Publicado: AlphaMed Press 2016
Materias:
Pluripotent Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954454/
https://ncbi.nlm.nih.gov/pubmed/27352929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0324
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