CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4(+) T cells with obesity

Obesity activates both innate and adaptive immune responses in adipose tissue, but the mechanisms critical for regulating these responses remain unknown. CD40/CD40L signaling provides bidirectional costimulatory signals between antigen-presenting cells and CD4(+) T cells, and CD40L expression is inc...

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Foilsithe in:J Leukoc Biol
Main Authors: Morris, David L., Oatmen, Kelsie E., Mergian, Taleen A., Cho, Kae Won, DelProposto, Jennifer L., Singer, Kanakadurga, Evans-Molina, Carmella, O’Rourke, Robert W., Lumeng, Carey N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Leukocyte Biology 2016
Ábhair:
Inflammation, Extracellular Mediators, & Effector Molecules
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4952010/
https://ncbi.nlm.nih.gov/pubmed/26658005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0115-009R
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