Hypoxia-mediated impaired erythrocyte Lands’ Cycle is pathogenic for sickle cell disease

Although Lands’ cycle was discovered in 1958, its function and cellular regulation in membrane homeostasis under physiological and pathological conditions remain largely unknown. Nonbiased high throughput metabolomic profiling revealed that Lands’ cycle was impaired leading to significantly elevated...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Wu, Hongyu, Bogdanov, Mikhail, Zhang, Yujin, Sun, Kaiqi, Zhao, Shushan, Song, Anren, Luo, Renna, Parchim, Nicholas F., Liu, Hong, Huang, Aji, Adebiyi, Morayo G., Jin, Jianping, Alexander, Danny C., Milburn, Michael V., Idowu, Modupe, Juneja, Harinder S., Kellems, Rodney E., Dowhan, William, Xia, Yang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951653/
https://ncbi.nlm.nih.gov/pubmed/27436223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29637
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