Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity

Erythrocyte possesses high sphingosine kinase 1 (SphK1) activity and is the major cell type supplying plasma sphingosine-1-phosphate, a signaling lipid regulating multiple physiological and pathological functions. Recent studies revealed that erythrocyte SphK1 activity is upregulated in sickle cell...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sun, Kaiqi, Zhang, Yujin, Bogdanov, Mikhail V., Wu, Hongyu, Song, Anren, Li, Jessica, Dowhan, William, Idowu, Modupe, Juneja, Harinder S., Molina, Jose G., Blackburn, Michael R., Kellems, Rodney E., Xia, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351509/
https://ncbi.nlm.nih.gov/pubmed/25587035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-595751
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