ZLM-7 exhibits anti-angiogenic effects via impaired endothelial cell function and blockade of VEGF/VEGFR-2 signaling

Inhibition of angiogenesis is a promising therapeutic strategy against cancer. In this study, we reported that ZLM-7, a combretastain A-4 (CA-4) derivative, exhibited anti-angiogenic activity in vitro and in vivo. In vitro, ZLM-7 induced microtubule cytoskeletal disassembly. It decreased VEGF-induce...

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Udgivet i:Oncotarget
Main Authors: Su, Min, Huang, Jingjia, Li, Jijia, Qin, Xiyuan, Tang, Xiaoning, Jin, Fang, Chen, Shali, Jiang, Chuanming, Zou, Zizheng, Peng, Kunjian, Nuruzzaman, Mohammed, Zhang, Jianting, Luo, Junli, Liu, Suyou, Luo, Zhiyong
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951348/
https://ncbi.nlm.nih.gov/pubmed/26967559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7968
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