Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia

Survival of cancer cells relies on the unfolded protein response (UPR) to resist stress triggered by the accumulation of misfolded proteins within the endoplasmic reticulum (ER). The IRE1α-XBP1 pathway, a key branch of the UPR, is activated in many cancers. Here, we show that the expression of both...

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Publicat a:Oncotarget
Autors principals: Sun, Haibo, Lin, De-Chen, Guo, Xiao, Masouleh, Behzad Kharabi, Gery, Sigal, Cao, Qi, Alkan, Serhan, Ikezoe, Takayuki, Akiba, Chie, Paquette, Ronald, Chien, Wenwen, Müller-Tidow, Carsten, Jing, Yang, Agelopoulos, Konstantin, Müschen, Markus, Koeffler, H. Phillip
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951325/
https://ncbi.nlm.nih.gov/pubmed/26934650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7702
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