Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder promoted by the constitutive tyrosine kinase activity of Bcr-Abl oncoprotein. Although treatment with the Bcr-Abl-inhibitor imatinib represents the first-line therapy against CML, almost 20-30% of patients develop chemotherapeutic resi...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Salizzato, Valentina, Borgo, Christian, Cesaro, Luca, Pinna, Lorenzo A., Donella-Deana, Arianna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951282/
https://ncbi.nlm.nih.gov/pubmed/26919095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7569
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