Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer

The expression of the tumor suppressor Merlin is compromised in nervous system malignancies due to genomic aberrations. We demonstrated for the first time, that in breast cancer, Merlin protein expression is lost due to proteasome-mediated elimination. Immunohistochemical analysis of tumor tissues f...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Morrow, K. Adam, Das, Shamik, Meng, Erhong, Menezes, Mitchell E., Bailey, Sarah K., Metge, Brandon J., Buchsbaum, Donald J., Samant, Rajeev S., Shevde, Lalita A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951266/
https://ncbi.nlm.nih.gov/pubmed/26908451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7494
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