Epidermal RAF prevents allergic skin disease

The RAS pathway is central to epidermal homeostasis, and its activation in tumors or in Rasopathies correlates with hyperproliferation. Downstream of RAS, RAF kinases are actionable targets regulating keratinocyte turnover; however, chemical RAF inhibitors paradoxically activate the pathway, promoti...

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Опубликовано в: :eLife
Главные авторы: Raguz, Josipa, Jeric, Ines, Niault, Theodora, Nowacka, Joanna Daniela, Kuzet, Sanya Eduarda, Rupp, Christian, Fischer, Irmgard, Biggi, Silvia, Borsello, Tiziana, Baccarini, Manuela
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2016
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951198/
https://ncbi.nlm.nih.gov/pubmed/27431613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14012
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