Epidermal RAF prevents allergic skin disease

The RAS pathway is central to epidermal homeostasis, and its activation in tumors or in Rasopathies correlates with hyperproliferation. Downstream of RAS, RAF kinases are actionable targets regulating keratinocyte turnover; however, chemical RAF inhibitors paradoxically activate the pathway, promoti...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Raguz, Josipa, Jeric, Ines, Niault, Theodora, Nowacka, Joanna Daniela, Kuzet, Sanya Eduarda, Rupp, Christian, Fischer, Irmgard, Biggi, Silvia, Borsello, Tiziana, Baccarini, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951198/
https://ncbi.nlm.nih.gov/pubmed/27431613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14012
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