Epidermal RAF prevents allergic skin disease

The RAS pathway is central to epidermal homeostasis, and its activation in tumors or in Rasopathies correlates with hyperproliferation. Downstream of RAS, RAF kinases are actionable targets regulating keratinocyte turnover; however, chemical RAF inhibitors paradoxically activate the pathway, promoti...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Raguz, Josipa, Jeric, Ines, Niault, Theodora, Nowacka, Joanna Daniela, Kuzet, Sanya Eduarda, Rupp, Christian, Fischer, Irmgard, Biggi, Silvia, Borsello, Tiziana, Baccarini, Manuela
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951198/
https://ncbi.nlm.nih.gov/pubmed/27431613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14012
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