Hypomethylation and Genetic Instability in Monosomy Blastocysts May Contribute to Decreased Implantation Potential

DNA methylation is a key epigenetic mechanism responsible for gene regulation, chromatin remodeling, and genome stability, playing a fundamental role during embryonic development. The aim of this study was to determine if these epigenetic marks are associated with chromosomal aneuploidy in human bla...

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Опубликовано в: :PLoS One
Главные авторы: McCallie, Blair R., Parks, Jason C., Patton, Alyssa L., Griffin, Darren K., Schoolcraft, William B., Katz-Jaffe, Mandy G.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951028/
https://ncbi.nlm.nih.gov/pubmed/27434648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159507
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