Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus

STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1). Understanding how pY701-STAT1 is regulated by intracellular signaling remains a major challenge. Here we find that pY...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Ren, Ying, Zhao, Peng, Liu, Jin, Yuan, Yukang, Cheng, Qiao, Zuo, Yibo, Qian, Liping, Liu, Chang, Guo, Tingting, Zhang, Liting, Wang, Xiaofang, Qian, Guanghui, Li, Lemin, Ge, Jun, Dai, Jianfeng, Xiong, Sidong, Zheng, Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951015/
https://ncbi.nlm.nih.gov/pubmed/27434509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005764
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